2′,2′-Difluorodeoxycytidine Metabolism and Mechanism of Action In Human Leukemia Cells

2′,2′-Difluorodeoxycytidine Metabolism and Mechanism of Action In Human Leukemia Cells

The toxicity of 2′,2′-difluorodeoxycytidine is due to the inhibition of DNA synthesis by a nucleotide metabolite by either direct inhibition of the process of DNA synthesis and/or to inhibition of ribonucleotide reductase.

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Veröffentlicht in:Nucleosides & nucleotides 1989-01, Vol.8 (5-6), p.775-785
Hauptverfasser: Plunkett, William, Gandi, Varsha, Chubb, Sherri, Nowak, Billie, Heinemann, Volker, Mineishi, Shin, Sen, Alina, Herte1, Larry W., Grindey, Gerald B.
Format: Artikel
Sprache:eng
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Zusammenfassung:The toxicity of 2′,2′-difluorodeoxycytidine is due to the inhibition of DNA synthesis by a nucleotide metabolite by either direct inhibition of the process of DNA synthesis and/or to inhibition of ribonucleotide reductase.
ISSN:0732-8311
1525-7770
DOI:10.1080/07328318908054215