Polyfunctional O-Substituted Hydroxylamines: Modification of Nucleic Acids, Inhibition of Sam-Decarboxylase

Polyfunctional O-Substituted Hydroxylamines: Modification of Nucleic Acids, Inhibition of Sam-Decarboxylase

Treo-1-aminooxy-2,3-dihydroxy-4-mercaptobu-tane is suggested for the introduction of reactive thiol groups via cytidine residues and/or 3′-end of nucleic acids. S-(5-desoxyadenosyl)-arainooxyethyl-thiomethyl hydroxy1-amine irreversibly inhibits SAM decarboxylase in 10 −3 M.

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Veröffentlicht in:Nucleosides & nucleotides 1987-01, Vol.6 (1-2), p.359-362
Hauptverfasser: Khomutov, A. R., Kritsky, A. M., Artamonova, E. Yu, Khomutov, R. M.
Format: Artikel
Sprache:eng
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Zusammenfassung:Treo-1-aminooxy-2,3-dihydroxy-4-mercaptobu-tane is suggested for the introduction of reactive thiol groups via cytidine residues and/or 3′-end of nucleic acids. S-(5-desoxyadenosyl)-arainooxyethyl-thiomethyl hydroxy1-amine irreversibly inhibits SAM decarboxylase in 10 −3 M.
ISSN:0732-8311
DOI:10.1080/07328318708056221