Analogues of Uridinediphosphatehexoses. A New Type of Protein Glycosylation Inhibitors That Show Antiviral Activity

Analogues of Uridinediphosphatehexoses. A New Type of Protein Glycosylation Inhibitors That Show Antiviral Activity

A series of analogues of UDP-Glc and UDP-GlcNAc prepared by reaction of protected hexoses with ClSO 2 NCO and 2′3′-O-isopropylideneuridine, inhibited glycosylation of proteins in HSV-1 infected HeLa cells and were active against several enveloped viruses.

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Veröffentlicht in:Nucleosides & nucleotides 1985-02, Vol.4 (1-2), p.149-151
Hauptverfasser: Camarasa, M. J., Fernández-resa, P., García-lópez, M. T., Heras, F. G. de las, Méndez-castrillónt, P. P., Alarcón, B., Carrasco, L.
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Sprache:eng
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Zusammenfassung:A series of analogues of UDP-Glc and UDP-GlcNAc prepared by reaction of protected hexoses with ClSO 2 NCO and 2′3′-O-isopropylideneuridine, inhibited glycosylation of proteins in HSV-1 infected HeLa cells and were active against several enveloped viruses.
ISSN:0732-8311
DOI:10.1080/07328318508077841