C-2 Epimerization of N-Acetylglucosamine in an Oligosaccharide Derived From Heparan Sulfate

The isolation of a heparan sulfate derived tetrasaccharide containing N-acetylmannosamine is described. The N-acetylmannosamine residue at the reducing terminus of heparin lyase derived tetrasaccharide is formed by base catalyzed C-2 epimerization of N-acetylglucosamine. This C-2 epimerization takes...

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Veröffentlicht in:Journal of carbohydrate chemistry 1996-04, Vol.15 (3), p.351-360
Hauptverfasser: Toida, Toshihiko, Vlahov, Iontcho R., Smith, April E., Hileman, Ronald E., Linhardt, Robert J.
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Sprache:eng
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Zusammenfassung:The isolation of a heparan sulfate derived tetrasaccharide containing N-acetylmannosamine is described. The N-acetylmannosamine residue at the reducing terminus of heparin lyase derived tetrasaccharide is formed by base catalyzed C-2 epimerization of N-acetylglucosamine. This C-2 epimerization takes place under very mild conditions suggesting that this residue may be formed in small amounts under physiologic conditions.
ISSN:0732-8303
1532-2327
DOI:10.1080/07328309608005658