New Surfactants with Sugar-Based Polar Heads Derived from Bile Acids: The N-Ursocholyl-d-glucosamine and N-Dehydrocholyl-d-glucosamine

A simple route to new surfactants with a sugar-based polar head group coupled to a steroidal hydrophobic group is described. These compounds, N-ursocholyl-d-glucosamine and N-dehydrocholyl-d-glucosamine, were obtained in a three stage process by acylation of d-glucosamine with N-acylthiazolidine-2-thiones derived from ursocholic and dehydrocholic acids.