Candida albicans stress mannoprotein, SMP200, enhances tumour necrosis factor secretion in the murine macrophage cell line ANA-I

Candida albicans stress mannoprotein, SMP200, enhances tumour necrosis factor secretion in the murine macrophage cell line ANA-I

Tumour necrosis factor (TNF) secretory activity has been studied in the murine macrophage cell line ANA-1 following in vitro exposure to Candida albicans 200 kDa stress mannoprotein (SMP200). Treatment of ANA-1 murine macrophages with 200 kDa stress mannoprotein results in increased TNF secretion. T...

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Veröffentlicht in:Medical mycology (Oxford) 1996, Vol.34 (3), p.219-222
Hauptverfasser: Pitzurra, L., Polonelli, L., Cantelli, C., Gerloni, M., Ponton, J., Bikandi, J., Blasi, E.
Format: Artikel
Sprache:eng
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Zusammenfassung:Tumour necrosis factor (TNF) secretory activity has been studied in the murine macrophage cell line ANA-1 following in vitro exposure to Candida albicans 200 kDa stress mannoprotein (SMP200). Treatment of ANA-1 murine macrophages with 200 kDa stress mannoprotein results in increased TNF secretion. The phenomenon is (i) dose- and time-dependent, (ii) abrogated by 200 kDa stress mannoprotein preincubation with a specific monoclonal antibody, and (iii) dependent on intact murine macrophage Ca2+/lmodulin-dependent protein kinase function.
ISSN:1369-3786
1460-2709
DOI:10.1080/02681219680000371