Residual vital ratio: predicting regrowth after radiofrequency ablation for benign thyroid nodules

To determine a novel quantitative index, residual vital ratio(RVR) by contrast-enhanced ultrasound(CEUS) with conventional Ultrasound(US), to early predict nodule regrowth after radiofrequency ablation (RFA)for benign thyroid nodules. This retrospective study evaluated 186 patients with 206 benign thyroid nodules underwent RFA. Patients were followed at 1, 3, 6, 12 months and every 12 months thereafter by conventional US, CEUS and clinical evaluation. RVR was defined as the initial ratio of residual vital volume to the total volume calculated by CEUS and conventional US at the first follow-up period after RFA. The relationship between RVR and regrowth was investigated. The mean volume of thyroid nodules was 10.09 ± 12.90 ml (range 0.40-71.39 ml), which decreased significantly to 2.33 ± 4.65 ml (range 0-36.75 ml) (p