Synthesis of 5-Ferrocenyl-4-Phenyl-4H-1,2,4-Triazole-3-Thiol and Its Derivatives

Synthesis of 5-Ferrocenyl-4-Phenyl-4H-1,2,4-Triazole-3-Thiol and Its Derivatives

A ferrocenyl thiosemicarbazide was prepared by treatment of ferrocene carboxylic acid hydrazide with phenylisothiocyanate. Cyclization of the thiosemicarbazide gave the 4,5-disubstituted-4H-1,2,4-triazole-3-thiol. Alkylation of 4,5-disubstituted- 4H-1,2,4-triazole-3-thiol with methyl iodide and prop...

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Veröffentlicht in:Synthesis and reactivity in inorganic and metal-organic chemistry 1994-08, Vol.24 (7), p.1121-1125
Hauptverfasser: Hui, Wu, Yulan, Zhang, Youhong, Hu, Shaozu, Wu
Format: Artikel
Sprache:eng
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Zusammenfassung:A ferrocenyl thiosemicarbazide was prepared by treatment of ferrocene carboxylic acid hydrazide with phenylisothiocyanate. Cyclization of the thiosemicarbazide gave the 4,5-disubstituted-4H-1,2,4-triazole-3-thiol. Alkylation of 4,5-disubstituted- 4H-1,2,4-triazole-3-thiol with methyl iodide and propyl iodide as alkylating agents led to its derivatives. All the compounds have been characterized by elemental analyses, IR and 1 H NMR spectra. Referee I: R. D. Theys Referee II: U. T. Mueller-Westerhoff
ISSN:0094-5714
1532-2440
DOI:10.1080/00945719408001388