A Study on the Stability of 5,5-Diamino-substituted-1,4,2-oxathiazoline Derivatives

A Study on the Stability of 5,5-Diamino-substituted-1,4,2-oxathiazoline Derivatives

5,5-Diamino-substituted-1,4,2-oxathiazoline derivatives 3 as potential prodrugs, which were easily prepared from hydroximoyl chlorides 1 and the appropriate thiourea derivatives 2, were decomposed instantaneously into isothiocyanates 4 and the corresponding urea derivatives 5 irrespective of the sub...

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Veröffentlicht in:Synthetic communications 1998-05, Vol.28 (10), p.1879-1884
Hauptverfasser: Jung, Keum Shin, Lee, Hong Jung, Song, Hyun Nam, Kim, Jae Nyoung
Format: Artikel
Sprache:eng
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Zusammenfassung:5,5-Diamino-substituted-1,4,2-oxathiazoline derivatives 3 as potential prodrugs, which were easily prepared from hydroximoyl chlorides 1 and the appropriate thiourea derivatives 2, were decomposed instantaneously into isothiocyanates 4 and the corresponding urea derivatives 5 irrespective of the substituents.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397919808007019