α-Amidoalkylation Reactions and Oxidation of Adducts of Benzimidazoles and Acyl Chlorides
Adducts 4 of benzimidazoles and acyl chlorides were successfully used as electrophilic reagents in an intermolecular α-amidoalkylation reaction toward ketones for synthesis of 2-(2-oxoalkyl)-1,3-diacyl-2,3-dihydrobenzimidazoles 6 and oxidized with KMnO 4 to 1,3-diacyl-2,3-dihydrobenzimidazol-2-ones...
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| Veröffentlicht in: | Synthetic communications 1998-05, Vol.28 (10), p.1857-1864 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Adducts 4 of benzimidazoles and acyl chlorides were successfully used as electrophilic reagents in an intermolecular α-amidoalkylation reaction toward ketones for synthesis of 2-(2-oxoalkyl)-1,3-diacyl-2,3-dihydrobenzimidazoles 6 and oxidized with KMnO
4
to 1,3-diacyl-2,3-dihydrobenzimidazol-2-ones 7. |
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| ISSN: | 0039-7911 1532-2432 |
| DOI: | 10.1080/00397919808007016 |