The Improved Synthesis of Enantiopure (S)-N-Arylmethyl-5-Oxoprolines

The Improved Synthesis of Enantiopure (S)-N-Arylmethyl-5-Oxoprolines

A mild procedure for the preparation of enantiopure N-alkylated (S)-(+)-5-oxoprolines 3a-r is described. The method starting from (S)-glutamic acid appears generally applicable to substrates with a wide range of substituents.

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Veröffentlicht in:Synthetic communications 1998-10, Vol.28 (19), p.3619-3624
Hauptverfasser: Marchalin, Stefan, Kadlecikova, Katarina, Bar, Nathalie, Decroix, Bernard
Format: Artikel
Sprache:eng
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Zusammenfassung:A mild procedure for the preparation of enantiopure N-alkylated (S)-(+)-5-oxoprolines 3a-r is described. The method starting from (S)-glutamic acid appears generally applicable to substrates with a wide range of substituents.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397919808004908