A Facile Route to Quinazolin-4(3H)-ones Functionalised at the 2-Position
Treatment of 2-methoxyacetamidobenzonitriles or 2-chloroacetamidobenzonitrile with UHP and K 2 CO 3 provides a convenient route to 2-methoxymethyl-or 2-chloromethylquinazolin-4(3H)-ones. In addition, demethylation of 2-methoxymethylquinazolin-4(3H)-ones with 48% HBr gives 2-hydroxymethylquinazolin-4...
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Veröffentlicht in: | Synthetic communications 1998-12, Vol.28 (24), p.4547-4559 |
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Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
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Zusammenfassung: | Treatment of 2-methoxyacetamidobenzonitriles or 2-chloroacetamidobenzonitrile with UHP and K
2
CO
3
provides a convenient route to 2-methoxymethyl-or 2-chloromethylquinazolin-4(3H)-ones. In addition, demethylation of 2-methoxymethylquinazolin-4(3H)-ones with 48% HBr gives 2-hydroxymethylquinazolin-4(3H)-ones. |
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ISSN: | 0039-7911 1532-2432 |
DOI: | 10.1080/00397919808004519 |