A Direct and High Yielding Route to 2-(5-Tetrazolyl) Substituted Benzopyran-4-ones: Synthesis of Pranlukast

A Direct and High Yielding Route to 2-(5-Tetrazolyl) Substituted Benzopyran-4-ones: Synthesis of Pranlukast

A direct and high yielding route to 2-(5-tetrazolyl)benzopyran-4-ones 1, including pranlukast 1a is described. This involves the Claisen condensation reaction between the relevant hydroxyacetophenone 2 and the ethyl ester of tetrazole-2-carboxylic acid 5 to give the 1,3-diketone 6, which is then cyc...

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Veröffentlicht in:Synthetic communications 1997-03, Vol.27 (6), p.1065-1073
Hauptverfasser: Geen, Graham R., Giles, Robert G., Grinter, Trevor J., Hayler, John D., Howie, Simon L. B., Johnson, Graham, Mann, Inderjit S., Novack, Vance J., Oxley, Paul W., Quick, John K., Smith, Neil
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Sprache:eng
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Zusammenfassung:A direct and high yielding route to 2-(5-tetrazolyl)benzopyran-4-ones 1, including pranlukast 1a is described. This involves the Claisen condensation reaction between the relevant hydroxyacetophenone 2 and the ethyl ester of tetrazole-2-carboxylic acid 5 to give the 1,3-diketone 6, which is then cyclised to give the desired benzopyran-4-ones 1.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397919708003052