An Efficient Synthesis of (±)-4-Amino-3-(4-chlorophenyl)-butyric Acid. (Baclofen)

An Efficient Synthesis of (±)-4-Amino-3-(4-chlorophenyl)-butyric Acid. (Baclofen)

A new preparation of baclofen is proposed. The key step involved a regioselective ring opening of 2-phenylaziridine with allylmagnesium bromide. Further oxydation of the side chain give access to 4-phenyl-pyrrolidin-2-one and to baclofen.

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Veröffentlicht in:Synthetic communications 1995-06, Vol.25 (12), p.1777-1782
Hauptverfasser: Ibuka, Toshiro, Schoenfelder, An[ggrave]ele, Bildstein, Patricia, Mann, Andre
Format: Artikel
Sprache:eng
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Zusammenfassung:A new preparation of baclofen is proposed. The key step involved a regioselective ring opening of 2-phenylaziridine with allylmagnesium bromide. Further oxydation of the side chain give access to 4-phenyl-pyrrolidin-2-one and to baclofen.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397919508015419