One-Pot Synthesis of Pyrimidine-5-Carboxaldehyde and Ethyl Pyrimidine-5-Carboxylate by Utilizing Pyrimidin-5-yl-Lithium

One-Pot Synthesis of Pyrimidine-5-Carboxaldehyde and Ethyl Pyrimidine-5-Carboxylate by Utilizing Pyrimidin-5-yl-Lithium

Pyrimidine-5-carboxaldehyde was prepared in a one-pot reaction from 5-bromo-pyrimidine via metal halogen exchange. Pyrimidin-5-yl-lithium reacted with formate ester and ethyl cyanoformate, forming respectively the aldehyde and carboxy ethyl ester.

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Veröffentlicht in:Synthetic communications 1994-01, Vol.24 (2), p.253-256
Hauptverfasser: Rho, Taikyun, Abuh, Yahaya F.
Format: Artikel
Sprache:eng
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Zusammenfassung:Pyrimidine-5-carboxaldehyde was prepared in a one-pot reaction from 5-bromo-pyrimidine via metal halogen exchange. Pyrimidin-5-yl-lithium reacted with formate ester and ethyl cyanoformate, forming respectively the aldehyde and carboxy ethyl ester.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397919408013824