A Practical Synthesis of 6-Acetylsalicylic Acid Methyl Ester
A new and efficient synthesis of the title compound is reported. The method includes a regioselective ortho-lithiation step in none polar solvents at an ambient temperature and the overall yield for 5 steps is more than 70% from a commercially available 3-hydroxyacetophenone.
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| Veröffentlicht in: | Synthetic communications 1994-10, Vol.24 (19), p.2749-2756 |
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| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | A new and efficient synthesis of the title compound is reported. The method includes a regioselective ortho-lithiation step in none polar solvents at an ambient temperature and the overall yield for 5 steps is more than 70% from a commercially available 3-hydroxyacetophenone. |
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| ISSN: | 0039-7911 1532-2432 |
| DOI: | 10.1080/00397919408010591 |