Facile Synthesis of a Carboxylic Linker on Halofuginone: A Method to Derivatize Haptens Containing Both Amine and Hydroxy Functionalities

Facile Synthesis of a Carboxylic Linker on Halofuginone: A Method to Derivatize Haptens Containing Both Amine and Hydroxy Functionalities

A succinic acid derivative of halofuginone was synthesized that could be easily bound to carrier proteins for halofuginone-specific antibody production. N-trimethylsilylimidazole was used to protect the hydroxyl group on halofuginone. Hydrolysis after treatment with succinic anhydride afforded the r...

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Veröffentlicht in:Synthetic communications 1993-08, Vol.23 (15), p.2191-2197
Hauptverfasser: Rowe, Loyd D., Beier, Ross C., Elissalde, Marcel H., Stanker, Larry H., Stipanovic, R. D.
Format: Artikel
Sprache:eng
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Zusammenfassung:A succinic acid derivative of halofuginone was synthesized that could be easily bound to carrier proteins for halofuginone-specific antibody production. N-trimethylsilylimidazole was used to protect the hydroxyl group on halofuginone. Hydrolysis after treatment with succinic anhydride afforded the required derivative.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397919308018614