Synthesis of Unsaturated Tricyclic Lactones. The Coupling of the Enol Triflate of β-Keto Lactones with Lithium Dimethylcuprate

Synthesis of Unsaturated Tricyclic Lactones. The Coupling of the Enol Triflate of β-Keto Lactones with Lithium Dimethylcuprate

The anions of selected β-keto lactones were transformed into their corresponding enol triflates. These enol triflates were coupled with lithium dimethylcuprate to afford tricyclic unsaturated /aciones, key intermediates for the synthesis of the biologically important natural product forskolin.

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Veröffentlicht in:Synthetic communications 1992-07, Vol.22 (13), p.1973-1984
Hauptverfasser: Bacigaluppo, José A., Colombo, Maria I., Zinczuk, Juan, Rúveda, Edmundo A.
Format: Artikel
Sprache:eng
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Zusammenfassung:The anions of selected β-keto lactones were transformed into their corresponding enol triflates. These enol triflates were coupled with lithium dimethylcuprate to afford tricyclic unsaturated /aciones, key intermediates for the synthesis of the biologically important natural product forskolin.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397919208021329