A route to optically active benzyl ester of (1-methyl-2-pyrrolidinyl)-acetic acid, an intermediate in the synthesis of Clemastine

A route to optically active benzyl ester of (1-methyl-2-pyrrolidinyl)-acetic acid, an intermediate in the synthesis of Clemastine

A short and efficient synthesis of the title compound based on racemate resolution is described.

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Veröffentlicht in:Synthetic communications 1990-07, Vol.20 (13), p.1977-1981
Hauptverfasser: Nikiforov, Theo, Stanchev, Stephan, Milenkov, Branimir, Dimitrov, Vladimir
Format: Artikel
Sprache:eng
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Beschreibung
Zusammenfassung:A short and efficient synthesis of the title compound based on racemate resolution is described.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397919008053128