A Convenient Synthesis of Aminomethylphosphonic Acid
A novel procedure for the preparation of aminometnylphosphonic acid (AMPA) is described. This compound. which has been shown to have some biological activity, is synthesized by treating N-hydroxymethylbenzamide with a mixture of phosphorous trichloride and trimethyl phosphite, followed by hydrolysis...
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| Veröffentlicht in: | Synthetic communications 1986-06, Vol.16 (7), p.733-739 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | A novel procedure for the preparation of aminometnylphosphonic acid (AMPA) is described. This compound. which has been shown to have some biological activity, is synthesized by treating N-hydroxymethylbenzamide with a mixture of phosphorous trichloride and trimethyl phosphite, followed by hydrolysis of the ester intermediate. |
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| ISSN: | 0039-7911 1532-2432 |
| DOI: | 10.1080/00397918608059652 |