Determination of Canrenone in Spironolactone Using Second Derivative Spectrophotometry

Determination of Canrenone in Spironolactone Using Second Derivative Spectrophotometry

Second derivative spectrophotometry has been used to determine canrenone (I), the main degredation product in spironolactone (II). Second derivative at 300 nm was found linearly related to concentration in the range of 0.2-1 mg% I has been determined in II down to concentration level of 0.2 mg%. The...

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Veröffentlicht in:Spectroscopy letters 1992-08, Vol.25 (5), p.721-732
Hauptverfasser: Wahbi, Abdel-Aziz M., Mahrous, M. S., Beltagy, Y. A., Issa, A. S., Lymona, H.
Format: Artikel
Sprache:eng
Schlagworte:
Analytical chemistry
Canrenone
Chemistry
Derivative Spectrophotometry
Exact sciences and technology
Impurity
Spectrometric and optical methods
Spironolactone
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Zusammenfassung:Second derivative spectrophotometry has been used to determine canrenone (I), the main degredation product in spironolactone (II). Second derivative at 300 nm was found linearly related to concentration in the range of 0.2-1 mg% I has been determined in II down to concentration level of 0.2 mg%. The results were found reproducible with a relative standard deviation of 1.7%.
ISSN:0038-7010
1532-2289
DOI:10.1080/00387019208020704