Spectrophotometric Determination of Metformin via Charge-Transfer Complex with Iodine

A spectroscopic method is described for the determination of Metformin based on its formation of molecular complex with iodine in dichloroethane. Quantitative measurements are made at the maximum absorption of 295nm. The molar ratio of the formed metformin-iodine complex is 1:1 as revealed by Job�...

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Veröffentlicht in:	Spectroscopy letters 1989-11, Vol.22 (9), p.1173-1181
Hauptverfasser:	El-bardicy, Mohamed G., El-khateeb, Sonia Z., Ahmad, Abdelkader S., Assaad, Hoda N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical biochemistry: general aspects, technics, instrumentation Analytical, structural and metabolic biochemistry Biological and medical sciences Determination Fundamental and applied biological sciences. Psychology Metformin Spectrophotometry
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Zusammenfassung:	A spectroscopic method is described for the determination of Metformin based on its formation of molecular complex with iodine in dichloroethane. Quantitative measurements are made at the maximum absorption of 295nm. The molar ratio of the formed metformin-iodine complex is 1:1 as revealed by Job's method. Beers' law is obeyed in the range 2-12 ug.ml −1 base solution. The proposed method is statistically comparable with the official B. P. method. When applied to pharmaceutical preparation, tablets, average percentage recovery of 99.97 ± 0.81 was obtained.
ISSN:	0038-7010 1532-2289
DOI:	10.1080/00387018908054014