Staphylococcus aureus skin/soft-tissue infections: The impact of SCCmec type and Panton-Valentine leukocidin

We assessed the role of Panton-Valentine leukocidin (PVL) and SCCmec type in community associated (CA) and healthcare associated (HC) Staphylococcus aureus (SA) skin/soft-tissue infections (STI). We prospectively monitored microbiology results (11 January 2005 to 6 January 2006), screened inpatients...

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Veröffentlicht in:	Scandinavian journal of infectious diseases 2008, Vol.40 (8), p.601-606
Hauptverfasser:	Jahamy, Houssein, Ganga, Roopa, Al Raiy, Basel, Shemes, Stephen, Nagappan, Vijayalakshmi, Sharma, Mamta, Riederer, Kathleen, Khatib, Riad
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Analysis of Variance Bacterial diseases Bacterial Toxins - genetics Bacterial Toxins - metabolism Biological and medical sciences Community-Acquired Infections - microbiology Cross Infection - microbiology Exotoxins - genetics Exotoxins - metabolism Female Genes, Bacterial Human bacterial diseases Humans Infectious diseases Latex Fixation Tests Leukocidins - genetics Leukocidins - metabolism Male Medical sciences Methicillin-Resistant Staphylococcus aureus - classification Methicillin-Resistant Staphylococcus aureus - genetics Methicillin-Resistant Staphylococcus aureus - pathogenicity Middle Aged Polymerase Chain Reaction Regression Analysis Soft Tissue Infections - microbiology Soft Tissue Infections - pathology Staphylococcal Infections - microbiology Staphylococcal Infections - pathology Staphylococcal infections, streptococcal infections, pneumococcal infections Staphylococcal Skin Infections - microbiology Staphylococcal Skin Infections - pathology Staphylococcus aureus Staphylococcus aureus - classification Staphylococcus aureus - genetics Staphylococcus aureus - pathogenicity
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Zusammenfassung:	We assessed the role of Panton-Valentine leukocidin (PVL) and SCCmec type in community associated (CA) and healthcare associated (HC) Staphylococcus aureus (SA) skin/soft-tissue infections (STI). We prospectively monitored microbiology results (11 January 2005 to 6 January 2006), screened inpatients with SA in tissue samples or blood, and selected adults with STI. We recorded clinical/microbiological characteristics, and tested saved isolates for PVL genes (real time PCR) and SCCmec type (conventional multiplex PCR). We encountered 204 patients. MRSA strains that accounted for 70.5% CA and 66.0% HC cases, caused more abscesses (55.7% vs 29.7%; p=0.001) and were often PVL-positive (68.9% vs 4.8%; p
ISSN:	0036-5548 1651-1980
DOI:	10.1080/00365540701877312