The reaction of urethane with mouse liver nucleic acids in vivo
Urethane, or a metabolite, has been shown to bind covalently to mouse liver DNA and protein, but not to RNA. Chromatographic examination of the acid hydrolysate of bound DNA showed that there was one radioactive peak which was separate from the major bases and nucleotides.
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| Veröffentlicht in: | Pathology 1971-01, Vol.3 (3), p.223-225 |
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| container_end_page | 225 |
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| container_issue | 3 |
| container_start_page | 223 |
| container_title | Pathology |
| container_volume | 3 |
| creator | Lawson, T.A. Pound, A.W. |
| description | Urethane, or a metabolite, has been shown to bind covalently to mouse liver DNA and protein, but not to RNA. Chromatographic examination of the acid hydrolysate of bound DNA showed that there was one radioactive peak which was separate from the major bases and nucleotides. |
| doi_str_mv | 10.1080/00313027109073737 |
| format | Article |
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Chromatographic examination of the acid hydrolysate of bound DNA showed that there was one radioactive peak which was separate from the major bases and nucleotides.</description><subject>Animals</subject><subject>Chromatography, Paper</subject><subject>DNA - metabolism</subject><subject>Injections, Intraperitoneal</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Mice</subject><subject>Nucleic Acids - metabolism</subject><subject>Proteins - metabolism</subject><subject>RNA - metabolism</subject><subject>Tritium</subject><subject>Urethane - administration & dosage</subject><subject>Urethane - metabolism</subject><issn>0031-3025</issn><issn>1465-3931</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF9LwzAUxYMoc04_gA9CvkD1pmnSFh9Ehv9g4Mt8LmlyQzO6ZiRtxW9vx4YvwrgP9-Gc34FzCLllcM-ggAcAzjikOYMScj7dGZmzTIqEl5ydk_leTyaDuCRXMW4AICuKYkZmgjExeebkad0gDah073xHvaVDwL5RHdJv1zd064eItHUjBtoNukWnqdLOROo6OrrRX5MLq9qIN8e_IF-vL-vle7L6fPtYPq8SzXnaJ9wIISyTKc8sxxJqBbZAiVJlpc7TrJalsKlOEWsjcimhtCizzOiaK2FrwxeEHXJ18DEGtNUuuK0KPxWDar9F9W-Libk7MLuh3qL5I47lJ_3xoLvO-rBVDaq2b7QKWG38ELqpz8n0I41T7dFhqKJ22Gk0LqDuK-PdCfoXhK999w</recordid><startdate>19710101</startdate><enddate>19710101</enddate><creator>Lawson, T.A.</creator><creator>Pound, A.W.</creator><general>Elsevier B.V</general><general>Informa UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19710101</creationdate><title>The reaction of urethane with mouse liver nucleic acids in vivo</title><author>Lawson, T.A. ; Pound, A.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-3d555f16234f3e90ba0f8e6e6a49c724b695f2c2eebd576609fe644dcb3a5fbd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1971</creationdate><topic>Animals</topic><topic>Chromatography, Paper</topic><topic>DNA - metabolism</topic><topic>Injections, Intraperitoneal</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Mice</topic><topic>Nucleic Acids - metabolism</topic><topic>Proteins - metabolism</topic><topic>RNA - metabolism</topic><topic>Tritium</topic><topic>Urethane - administration & dosage</topic><topic>Urethane - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lawson, T.A.</creatorcontrib><creatorcontrib>Pound, A.W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lawson, T.A.</au><au>Pound, A.W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The reaction of urethane with mouse liver nucleic acids in vivo</atitle><jtitle>Pathology</jtitle><addtitle>Pathology</addtitle><date>1971-01-01</date><risdate>1971</risdate><volume>3</volume><issue>3</issue><spage>223</spage><epage>225</epage><pages>223-225</pages><issn>0031-3025</issn><eissn>1465-3931</eissn><abstract>Urethane, or a metabolite, has been shown to bind covalently to mouse liver DNA and protein, but not to RNA. 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| fulltext | fulltext |
| identifier | ISSN: 0031-3025 |
| ispartof | Pathology, 1971-01, Vol.3 (3), p.223-225 |
| issn | 0031-3025 1465-3931 |
| language | eng |
| recordid | cdi_crossref_primary_10_1080_00313027109073737 |
| source | MEDLINE; Taylor & Francis:Master (3349 titles); Alma/SFX Local Collection |
| subjects | Animals Chromatography, Paper DNA - metabolism Injections, Intraperitoneal Liver - metabolism Male Mice Nucleic Acids - metabolism Proteins - metabolism RNA - metabolism Tritium Urethane - administration & dosage Urethane - metabolism |
| title | The reaction of urethane with mouse liver nucleic acids in vivo |
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