The reaction of urethane with mouse liver nucleic acids in vivo

Urethane, or a metabolite, has been shown to bind covalently to mouse liver DNA and protein, but not to RNA. Chromatographic examination of the acid hydrolysate of bound DNA showed that there was one radioactive peak which was separate from the major bases and nucleotides.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pathology 1971-01, Vol.3 (3), p.223-225
Hauptverfasser:	Lawson, T.A., Pound, A.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromatography, Paper DNA - metabolism Injections, Intraperitoneal Liver - metabolism Male Mice Nucleic Acids - metabolism Proteins - metabolism RNA - metabolism Tritium Urethane - administration & dosage Urethane - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Urethane, or a metabolite, has been shown to bind covalently to mouse liver DNA and protein, but not to RNA. Chromatographic examination of the acid hydrolysate of bound DNA showed that there was one radioactive peak which was separate from the major bases and nucleotides.
ISSN:	0031-3025 1465-3931
DOI:	10.1080/00313027109073737