Cultural Conditions and Strain Improvement for Production of Bactobolin
The cultural conditions for the production of bactobolin, an antitumor antibiotic produced by Pseudomonas yoshitomiensis, were studied using a mutant strain, C-17-20. The following cultural conditions were found to be suitable: 2.0% mannitol, 0.25% dried yeast, 0.5% (NH 4 ) 2 SO 4 , 0.4% KCl, 0.02%...
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| Veröffentlicht in: | Agricultural and biological chemistry 1983-01, Vol.47 (5), p.929-934 |
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| container_issue | 5 |
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| container_title | Agricultural and biological chemistry |
| container_volume | 47 |
| creator | Munakata, Tomohiko Ikeda, Yoshifumi Matsuki, Hideo Isagai, Katsuyoshi |
| description | The cultural conditions for the production of bactobolin, an antitumor antibiotic produced by Pseudomonas yoshitomiensis, were studied using a mutant strain, C-17-20. The following cultural conditions were found to be suitable: 2.0% mannitol, 0.25% dried yeast, 0.5% (NH
4
)
2
SO
4
, 0.4% KCl, 0.02% K
2
HPO
4
and 0.8% CaCO
3
; temperature, 25°C. The highest bactobolin production under the conditions was 189 μg/ml, although the wild strain, Y-12278, produced only 4 μg/ml in the basal conditions. |
| doi_str_mv | 10.1080/00021369.1983.10865772 |
| format | Article |
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4
)
2
SO
4
, 0.4% KCl, 0.02% K
2
HPO
4
and 0.8% CaCO
3
; temperature, 25°C. The highest bactobolin production under the conditions was 189 μg/ml, although the wild strain, Y-12278, produced only 4 μg/ml in the basal conditions.</description><identifier>ISSN: 0002-1369</identifier><identifier>DOI: 10.1080/00021369.1983.10865772</identifier><language>eng</language><publisher>Taylor & Francis</publisher><ispartof>Agricultural and biological chemistry, 1983-01, Vol.47 (5), p.929-934</ispartof><rights>Copyright, 1983, by the Agricultural Chemical Society of Japan 1983</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Munakata, Tomohiko</creatorcontrib><creatorcontrib>Ikeda, Yoshifumi</creatorcontrib><creatorcontrib>Matsuki, Hideo</creatorcontrib><creatorcontrib>Isagai, Katsuyoshi</creatorcontrib><title>Cultural Conditions and Strain Improvement for Production of Bactobolin</title><title>Agricultural and biological chemistry</title><description>The cultural conditions for the production of bactobolin, an antitumor antibiotic produced by Pseudomonas yoshitomiensis, were studied using a mutant strain, C-17-20. The following cultural conditions were found to be suitable: 2.0% mannitol, 0.25% dried yeast, 0.5% (NH
4
)
2
SO
4
, 0.4% KCl, 0.02% K
2
HPO
4
and 0.8% CaCO
3
; temperature, 25°C. The highest bactobolin production under the conditions was 189 μg/ml, although the wild strain, Y-12278, produced only 4 μg/ml in the basal conditions.</description><issn>0002-1369</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><recordid>eNqFUMtKAzEUzULBWv0Fycrd1DuTziPLWrQKBQV1HW7zgEgmqUlG6d87Q-3a1YV7HpxzCLkpYVFCB3cAUJWs4YuSd2x6NXXbVmdkNgHFhFyQy5Q-AWpgADOyWQ8uDxEdXQevbLbBJ4pe0bcc0Xr63O9j-Na99pmaEOlrDGqQE40GQ-9R5rALzvorcm7QJX39d-fk4_Hhff1UbF82z-vVtpBVx3OBjBswS16xtmasMVLp1kjgJbLOLEvZ1WNkzSSqmtUMKsXbujW4kwo5k4qxObk9-o6xvgadsuhtkto59DoMSYwV265pmpHYHIkyhpSiNmIfbY_xIEoQ01bitJWYthKnrUbh6ii0fizc40-ITomMBxeiieilTYL94_ELXTRzSw</recordid><startdate>19830101</startdate><enddate>19830101</enddate><creator>Munakata, Tomohiko</creator><creator>Ikeda, Yoshifumi</creator><creator>Matsuki, Hideo</creator><creator>Isagai, Katsuyoshi</creator><general>Taylor & Francis</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>19830101</creationdate><title>Cultural Conditions and Strain Improvement for Production of Bactobolin</title><author>Munakata, Tomohiko ; Ikeda, Yoshifumi ; Matsuki, Hideo ; Isagai, Katsuyoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c289t-a39f0f492375336fcde7fc091a38f41c85086e3cad535302d9757fabcda93cd33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Munakata, Tomohiko</creatorcontrib><creatorcontrib>Ikeda, Yoshifumi</creatorcontrib><creatorcontrib>Matsuki, Hideo</creatorcontrib><creatorcontrib>Isagai, Katsuyoshi</creatorcontrib><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Agricultural and biological chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Munakata, Tomohiko</au><au>Ikeda, Yoshifumi</au><au>Matsuki, Hideo</au><au>Isagai, Katsuyoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cultural Conditions and Strain Improvement for Production of Bactobolin</atitle><jtitle>Agricultural and biological chemistry</jtitle><date>1983-01-01</date><risdate>1983</risdate><volume>47</volume><issue>5</issue><spage>929</spage><epage>934</epage><pages>929-934</pages><issn>0002-1369</issn><abstract>The cultural conditions for the production of bactobolin, an antitumor antibiotic produced by Pseudomonas yoshitomiensis, were studied using a mutant strain, C-17-20. The following cultural conditions were found to be suitable: 2.0% mannitol, 0.25% dried yeast, 0.5% (NH
4
)
2
SO
4
, 0.4% KCl, 0.02% K
2
HPO
4
and 0.8% CaCO
3
; temperature, 25°C. The highest bactobolin production under the conditions was 189 μg/ml, although the wild strain, Y-12278, produced only 4 μg/ml in the basal conditions.</abstract><pub>Taylor & Francis</pub><doi>10.1080/00021369.1983.10865772</doi><tpages>6</tpages></addata></record> |
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| ispartof | Agricultural and biological chemistry, 1983-01, Vol.47 (5), p.929-934 |
| issn | 0002-1369 |
| language | eng |
| recordid | cdi_crossref_primary_10_1080_00021369_1983_10865772 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Free Full-Text Journals in Chemistry |
| title | Cultural Conditions and Strain Improvement for Production of Bactobolin |
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