Nicotine-induced Endocytosis of Amiloride-sensitive Sodium Channels in Human Nasal Epithelium

In previous studies we developed and introduced a method to examine the transport mechanisms of ions in primary cell cultures of human nasal epithelium. In the current study, substances, especially nicotine, that influence these mechanisms are investigated. Specimens of nasal and paranasal epitheliu...

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Veröffentlicht in:	Acta oto-laryngologica 2000-01, Vol.120 (2), p.286-290
Hauptverfasser:	T, Klimek, H, Glanz, C, Ruckes-Nilges, W, Van Driessche, M, Weber W
Format:	Artikel
Sprache:	eng
Schlagworte:	Amiloride - pharmacology Calcium - metabolism Cells, Cultured Endocytosis - drug effects Endocytosis - physiology Humans Membrane Potentials - drug effects Nasal Mucosa - drug effects Nasal Mucosa - physiopathology Nicotine - pharmacology Protein Kinase C - physiology Smoking - physiopathology Sodium Channels - drug effects Sodium Channels - physiology
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Beschreibung
Zusammenfassung:	In previous studies we developed and introduced a method to examine the transport mechanisms of ions in primary cell cultures of human nasal epithelium. In the current study, substances, especially nicotine, that influence these mechanisms are investigated. Specimens of nasal and paranasal epithelium of patients treated by endonasal surgery because of chronic sinusitis (
ISSN:	0001-6489 1651-2251
DOI:	10.1080/000164800750001107