cAMP-dependent Protein Kinase Phosphorylation Produces Interdomain Movement in SUR2B Leading to Activation of the Vascular KATP Channel

Vascular ATP-sensitive K+ channels are activated by multiple vasodilating hormones and neurotransmitters via PKA. A critical PKA phosphorylation site (Ser-1387) is found in the second nucleotide-binding domain (NBD2) of the SUR2B subunit. To understand how phosphorylation at Ser-1387 leads to change...

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Veröffentlicht in:	The Journal of biological chemistry 2008-03, Vol.283 (12), p.7523-7530
Hauptverfasser:	Shi, Yun, Chen, Xianfeng, Wu, Zhongying, Shi, Weiwei, Yang, Yang, Cui, Ningren, Jiang, Chun, Harrison, Robert W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Animals ATP-Binding Cassette Transporters - chemistry ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Cyclic AMP-Dependent Protein Kinases - chemistry Cyclic AMP-Dependent Protein Kinases - genetics Cyclic AMP-Dependent Protein Kinases - metabolism Disulfides - chemistry Disulfides - metabolism KATP Channels - chemistry KATP Channels - genetics KATP Channels - metabolism Membrane Transport, Structure, Function, and Biogenesis Models, Molecular Muscle, Smooth, Vascular - chemistry Muscle, Smooth, Vascular - metabolism Oxidation-Reduction Phosphorylation Potassium Channels - chemistry Potassium Channels - genetics Potassium Channels - metabolism Potassium Channels, Inwardly Rectifying - chemistry Potassium Channels, Inwardly Rectifying - genetics Potassium Channels, Inwardly Rectifying - metabolism Protein Structure, Tertiary - physiology Rats Receptors, Drug - chemistry Receptors, Drug - genetics Receptors, Drug - metabolism Sulfonylurea Receptors
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