Localization of an NH2-terminal Disease-causing Mutation Hot Spot to the “Clamp” Region in the Three-dimensional Structure of the Cardiac Ryanodine Receptor

A region between residues 414 and 466 in the cardiac ryanodine receptor (RyR2) harbors more than half of the known NH2-terminal mutations associated with cardiac arrhythmias and sudden death. To gain insight into the structural basis of this NH2-terminal mutation hot spot, we have determined its loc...

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Veröffentlicht in:	The Journal of biological chemistry 2007-06, Vol.282 (24), p.17785-17793
Hauptverfasser:	Wang, Ruiwu, Chen, Wenqian, Cai, Shitian, Zhang, Jing, Bolstad, Jeff, Wagenknecht, Terence, Liu, Zheng, Chen, S. R. Wayne
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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