Orientation and Cellular Distribution of Membrane-bound Catechol-O-methyltransferase in Cortical Neurons

Catechol-O-methyltransferase (COMT) is a key enzyme for inactivation and metabolism of catechols, including dopamine, norepinephrine, caffeine, and estrogens. It plays an important role in cognition, arousal, pain sensitivity, and stress reactivity in humans and in animal models. The human COMT gene...

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Veröffentlicht in:	The Journal of biological chemistry 2011-10, Vol.286 (40), p.34752-34760
Hauptverfasser:	Chen, Jingshan, Song, Jian, Yuan, Peixiong, Tian, Qingjun, Ji, Yuanyuan, Ren-Patterson, Renee, Liu, Guangping, Sei, Yoshitasu, Weinberger, Daniel R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Catechol-o-methyltransferase Cell Surface Enzymes Cytotoxicity Dopamine Enzyme Inhibitors Neural Metabolism Neurons Parkinson Disease Schizophrenia Tolcapone
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