The Super Anti-apoptotic Factor Bcl-xFNK Constructed by Disturbing Intramolecular Polar Interactions in Rat Bcl-xL

A powerful artificial anti-apoptotic factor will be useful for medical applications of the future therapies for many diseases by prolonging survival of sick cells. For constructing it, we designed the super anti-apoptotic factor by disturbing three intramolecular polar interactions among α-helix str...

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Veröffentlicht in:	The Journal of biological chemistry 2000-11, Vol.275 (47), p.37240-37245
Hauptverfasser:	Asoh, Sadamitsu, Ohtsu, Takashi, Ohta, Shigeo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis bcl-X Protein CHO Cells Cricetinae Humans Hydrogen Bonding Jurkat Cells Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases - metabolism Models, Molecular Molecular Conformation Mutagenesis, Site-Directed Proto-Oncogene Proteins c-bcl-2 - chemical synthesis Proto-Oncogene Proteins c-bcl-2 - chemistry Proto-Oncogene Proteins c-bcl-2 - genetics Rats Transfection
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