Biosynthesis of Vitamin B6 inRhizobium

The biosynthetic pathway of pyridoxol (vitamin B6) in Rhizobium was clarified by studies on the incorporation of 13C- or 15N-labeled precursors into pyridoxol or its biosynthetic intermediates. Pyridoxol was formed by ring closure of two compounds, 1-deoxy-d-xylulose and 4-hydroxy-l-threonine. The f...

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Veröffentlicht in:The Journal of biological chemistry 2000-04, Vol.275 (15), p.11300-11305
Hauptverfasser: Tazoe, Masaaki, Ichikawa, Keiko, Hoshino, Tatsuo
Format: Artikel
Sprache:eng
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Zusammenfassung:The biosynthetic pathway of pyridoxol (vitamin B6) in Rhizobium was clarified by studies on the incorporation of 13C- or 15N-labeled precursors into pyridoxol or its biosynthetic intermediates. Pyridoxol was formed by ring closure of two compounds, 1-deoxy-d-xylulose and 4-hydroxy-l-threonine. The former was formed from d-glyceraldehyde and pyruvate through decarboxylation of pyruvate, and the latter from glycine and glycolaldehyde.
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.275.15.11300