Structural Integrity of the γ-Carboxyglutamic Acid Domain of Human Blood Coagulation Factor IXa Is Required for Its Binding to Cofactor VIIIa (∗)

This report describes the analysis of a novel mutant human factor IX protein from a patient with hemophilia B (factor IX activity

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Veröffentlicht in:	The Journal of biological chemistry 1996-02, Vol.271 (7), p.3869-3876
Hauptverfasser:	Larson, Peter J., Stanfield-Oakley, Sherry A., VanDusen, William J., Kasper, Carol K., Smith, Kenneth J., Monroe, Dougald M., High, Katherine A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Amino Acid Sequence Arginine Base Sequence Binding Sites DNA - blood DNA Mutational Analysis Exons Factor IX - chemistry Factor IXa - chemistry Factor IXa - metabolism Factor VIIIa - metabolism Factor X - chemistry Factor X - genetics Factor X - isolation & purification Glycine Guanine Hemophilia B - blood Hemophilia B - genetics Humans Kinetics Mathematics Models, Theoretical Molecular Sequence Data Point Mutation Prothrombin Time Triazines
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Beschreibung
Zusammenfassung:	This report describes the analysis of a novel mutant human factor IX protein from a patient with hemophilia B (factor IX activity
ISSN:	0021-9258 1083-351X
DOI:	10.1074/jbc.271.7.3869