Macrophages Specifically Regulate the Concentration of Their Own Growth Factor in the Circulation

The physiological mechanism of clearance of the mononuclear phagocyte growth factor, colony-stimulating factor 1 (CSF-1), from the circulation of normal mice was investigated by following the fate of a trace amount of i.v. injected 125I-labeled CSF-1. Macrophages selectively cleared CSF-1 by CSF-1 r...

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Veröffentlicht in:Proc. Natl. Acad. Sci. U.S.A.; (United States) 1987-09, Vol.84 (17), p.6179-6183
Hauptverfasser: Bartocci, A., Mastrogiannis, D. S., Migliorati, G., Stockert, R. J., Wolkoff, A. W., Stanley, E. R.
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Sprache:eng
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Zusammenfassung:The physiological mechanism of clearance of the mononuclear phagocyte growth factor, colony-stimulating factor 1 (CSF-1), from the circulation of normal mice was investigated by following the fate of a trace amount of i.v. injected 125I-labeled CSF-1. Macrophages selectively cleared CSF-1 by CSF-1 receptor-mediated endocytosis and degraded the growth factor intracellularly. This manner of clearance provides a feedback control mechanism whereby the rate of macrophage production is determined by the number of mature macrophages.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.84.17.6179