Human c-fos Oncogene Mapped within Chromosomal Region 14q21 → q31

Human c-fos Oncogene Mapped within Chromosomal Region 14q21 → q31

The human cellular homolog (c-fos) of the transforming gene of Finkel-Biskis-Jinkins (FBJ) murine osteosarcoma virus was mapped to a single human chromosome. DNA from a series of 31 mouse-human somatic cell hybrid lines was probed with v- and c-fos molecular clones by Southern blotting. Human c-fos...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1984-09, Vol.81 (18), p.5826-5830
Hauptverfasser: Barker, P. E., Rabin, Mark, Watson, Michael, Breg, W. Roy, Ruddle, Frank H., Verma, Inder M.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell Line
Cell lines
Cell Transformation, Neoplastic
Chromosome Mapping
Chromosomes
Chromosomes, Human, 13-15
Cloning, Molecular
DNA
DNA probes
fos genes
Genes
Genes, Viral
Humans
Hybrid cells
Hybrid Cells - physiology
Hybridity
In situ hybridization
Mice
Nucleic Acid Hybridization
Oncogenes
Sarcoma Viruses, Murine - genetics
Translocation, Genetic
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Zusammenfassung:The human cellular homolog (c-fos) of the transforming gene of Finkel-Biskis-Jinkins (FBJ) murine osteosarcoma virus was mapped to a single human chromosome. DNA from a series of 31 mouse-human somatic cell hybrid lines was probed with v- and c-fos molecular clones by Southern blotting. Human c-fos segregated with the distal region of the long arm of human chromosome 14. In situ hybridization of125I-labeled human c-fos probe to normal human metaphase chromosomes independently confirmed these results and localized the c-fos oncogene to region 14q21 → q31.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.81.18.5826