Human Synoviocytes: Activation and Desensitization by Prostaglandins and 1-epinephrine

The human synoviocyte increases its intracellular adenosine 3′:5′-cyclic monophosphate (cAMP) concentration significantly after incubation with prostaglandin E1, prostaglandin E2, or l-epinephrine. The cells can be desensitized to these same hormones. Hormone-induced desensitization is receptor site...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1975-08, Vol.72 (8), p.3124-3128
Hauptverfasser:	Newcombe, David S., Ciosek, Carl P., Ishikawa, Yoshinori, Fahey, John V.
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-Cyclic-AMP Phosphodiesterases - metabolism Cell biology Cell culture techniques Cell growth Cell lines Cells Cells, Cultured Cyclic AMP - metabolism Cyclic nucleotides Enzyme Activation - drug effects Epinephrine - pharmacology Hormones Humans Inurement Prostaglandins Prostaglandins E - pharmacology Receptors Synovial Membrane - cytology Synovial Membrane - drug effects Synovial Membrane - metabolism Tendons - cytology Tendons - drug effects Tendons - metabolism Theophylline - pharmacology
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Zusammenfassung:	The human synoviocyte increases its intracellular adenosine 3′:5′-cyclic monophosphate (cAMP) concentration significantly after incubation with prostaglandin E1, prostaglandin E2, or l-epinephrine. The cells can be desensitized to these same hormones. Hormone-induced desensitization is receptor site specific and associated with a significant increase in intracellular 3′:5′-cyclic AMP phosphodiesterase (EC 3.1.4. 17; 3′:5′-cyclic AMP 5′-nucleotidohydrolase) activity, whereas cAMP-induced desensitization is not hormone specific.
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.72.8.3124