Prolongation of the Life-Span in Mice Adapted to Large Amounts of L-Dopa

Various concentrations of L-dopa (levodopa, L-3,4-dihydroxyphenylalanine) were incorporated in the diets of young male Swiss albino mice, and the highest concentrations to which these mice became adapted within 3 weeks were determined. One such concentration administered indefinitely eventually indu...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1974-06, Vol.71 (6), p.2466-2469
Hauptverfasser:	Cotzias, George C., Miller, Samuel T., Nicholson, Alexander R., Maston, William H., Tang, Lily C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Albinism Animals Biological Sciences: Medical Sciences Body weight Corneal Opacity - chemically induced Diet Dihydroxyphenylalanine - administration & dosage Dihydroxyphenylalanine - adverse effects Dihydroxyphenylalanine - pharmacology Dosage Dose-Response Relationship, Drug Female Food consumption Longevity Longevity - drug effects Male Male animals Mice Motor activity Opacity Parkinson disease
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Beschreibung
Zusammenfassung:	Various concentrations of L-dopa (levodopa, L-3,4-dihydroxyphenylalanine) were incorporated in the diets of young male Swiss albino mice, and the highest concentrations to which these mice became adapted within 3 weeks were determined. One such concentration administered indefinitely eventually induced a youthful appearance, a significantly prolonged life-span, but also corneal opacities compatible with traumatic or chemical keratitis.
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.71.6.2466