Regulation of Adenylate Kinase and Creatine Kinase Activities in Myogenic Cells

Regulation of Adenylate Kinase and Creatine Kinase Activities in Myogenic Cells

The regulation of the specific activities of adenylate kinase (EC 2.7.4.3) and creatine kinase (EC 2.7.3.2) in myogenic cell lines is independent of cell fusion. The observed increases in enzyme specific activities are cell density dependent, and may be further broken down into contributions from an...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1974-06, Vol.71 (6), p.2377-2381
Hauptverfasser: Tarikas, Helgi, Schubert, David
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological Sciences: Physiology
Cell Count
Cell culture techniques
Cell Differentiation
Cell Fusion
Cell Line
Cell lines
Cellular differentiation
Creatine
Creatine Kinase - metabolism
Cultured cells
Enzyme activity
Enzymes
Muscles - embryology
Muscles - enzymology
Phosphotransferases - metabolism
Physiological regulation
Rats
Stem cells
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Zusammenfassung:The regulation of the specific activities of adenylate kinase (EC 2.7.4.3) and creatine kinase (EC 2.7.3.2) in myogenic cell lines is independent of cell fusion. The observed increases in enzyme specific activities are cell density dependent, and may be further broken down into contributions from an increase in enzyme activity per cell and a decrease in protein per cell. Only the former appears to be affected by medium conditioning.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.71.6.2377