Facilitation of Development of Resistance to Morphine Analgesia by Desglycinamide 9 -Lysine Vasopressin

Facilitation of Development of Resistance to Morphine Analgesia by Desglycinamide 9 -Lysine Vasopressin

Desglycinamide 9 -lysine vasopressin facilitates development of resistance to the analgesic action of morphine in mice if morphine is administered before the peptide. Desglycinamide 9 -lysine vasopressin is not a morphine antagonist, and does not appear to cause either hyperalgesia or alteration of...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1974-05, Vol.71 (5), p.1852-1856
Hauptverfasser: Krivoy, William A., Zimmermann, Emery, Lande, Saul
Format: Artikel
Sprache:eng
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Zusammenfassung:Desglycinamide 9 -lysine vasopressin facilitates development of resistance to the analgesic action of morphine in mice if morphine is administered before the peptide. Desglycinamide 9 -lysine vasopressin is not a morphine antagonist, and does not appear to cause either hyperalgesia or alteration of the response to the technique used for evaluating analgesia.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.71.5.1852