Human Antigen and Enzyme Markers in Man-Chinese Hamster Somatic Cell Hybrids: Evidence for Synteny Between the HL-A, PGM 3 , ME 1 , and IPO-B Loci

Human Antigen and Enzyme Markers in Man-Chinese Hamster Somatic Cell Hybrids: Evidence for Synteny Between the HL-A, PGM 3 , ME 1 , and IPO-B Loci

In man-Chinese hamster somatic cell hybrids the segregation of the loci for 27 human enzyme markers and the species-specific surface antigens, including the HL-A histocompatibility antigens, was studied. The results show a synteny of the human loci for phosphoglucomutase 3, cytoplasmic malic enzyme,...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1974-03, Vol.71 (3), p.962-965
Hauptverfasser: Someren, H. Van, Westerveld, A., Hagemeijer, A., Mees, J. R., Khan, P. Meera, Zaalberg, O. B.
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Sprache:eng
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Zusammenfassung:In man-Chinese hamster somatic cell hybrids the segregation of the loci for 27 human enzyme markers and the species-specific surface antigens, including the HL-A histocompatibility antigens, was studied. The results show a synteny of the human loci for phosphoglucomutase 3, cytoplasmic malic enzyme, tetrameric indophenol oxidase, and HL-A. Furthermore, evidence is presented that the loci for the human species-specific antigens are distributed over several chromosomes.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.71.3.962