Conformational Relationships between Analogs of Acetylcholine and those of Local Anesthetics in Solution

Conformational Relationships between Analogs of Acetylcholine and those of Local Anesthetics in Solution

Conformations of analogs of acetylcholine and of related local anesthetics, in which either of the oxygen atoms had been replaced by other heteroatoms, were studied in solution by nuclear magnetic resonance. Several correlations between structure and conformation could be made.

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Bibliographische Detailangaben
Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1972-11, Vol.69 (11), p.3416-3419
Hauptverfasser: Makriyannis, Alexandros, Sullivan, Richard F., Mautner, Henry G.
Format: Artikel
Sprache:eng
Schlagworte:
Acetylcholine
Action potentials
Benzamides
Benzoates
Biological Sciences: Biochemistry
Biopolymers
Crystals
Esters
Ethylamines
Local anesthetics
Methylamines
Molecular Conformation
Molecules
Oxygen
Selenium
Solvents
Sulfur
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Beschreibung
Zusammenfassung:Conformations of analogs of acetylcholine and of related local anesthetics, in which either of the oxygen atoms had been replaced by other heteroatoms, were studied in solution by nuclear magnetic resonance. Several correlations between structure and conformation could be made.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.69.11.3416