Dynamics and control of state-dependent networks for probing genomic organization

A state-dependent dynamic network is a collection of elements that interact through a network, whose geometry evolves as the state of the elements changes over time. The genome is an intriguing example of a state-dependent network, where chromosomal geometry directly relates to genomic activity, whi...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 2011-10, Vol.108 (42), p.17257-17262
Hauptverfasser: Rajapakse, Indika, Groudine, Mark, Mesbahi, Mehran
Format: Artikel
Sprache:eng
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Zusammenfassung:A state-dependent dynamic network is a collection of elements that interact through a network, whose geometry evolves as the state of the elements changes over time. The genome is an intriguing example of a state-dependent network, where chromosomal geometry directly relates to genomic activity, which in turn strongly correlates with geometry. Here we examine various aspects of a genomic state-dependent dynamic network. In particular, we elaborate on one of the important ramifications of viewing genomic networks as being state-dependent, namely, their controllability during processes of genomic reorganization such as in cell differentiation.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1113249108