CD8⁺ T regulatory cells express the Ly49 Class I MHC receptor and are defective in autoimmune prone B6-Yaa mice
The immune system includes a subpopulation of CD8⁺ T cells equipped to inhibit the expansion of follicular T helper (TFH) cells, resulting in suppression of autoantibody production and associated lupus-like disease. These CD8⁺ T regulatory (Treg) cells recognize Qa-1/peptide complexes on target TFH...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2011-02, Vol.108 (5), p.2010-2015 |
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| container_issue | 5 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 108 |
| creator | Kim, Hye-Jung Wang, Xuan Radfar, Soroosh Sproule, Thomas J Roopenian, Derry C Cantor, Harvey |
| description | The immune system includes a subpopulation of CD8⁺ T cells equipped to inhibit the expansion of follicular T helper (TFH) cells, resulting in suppression of autoantibody production and associated lupus-like disease. These CD8⁺ T regulatory (Treg) cells recognize Qa-1/peptide complexes on target TFH cells and depend on the IL-15 cytokine for development and function. Here we show that these CD8⁺ Treg cells express a triad of surface receptors--CD44, CD122, and the class I MHC receptor Ly49--and account for |
| doi_str_mv | 10.1073/pnas.1018974108 |
| format | Article |
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These CD8⁺ T regulatory (Treg) cells recognize Qa-1/peptide complexes on target TFH cells and depend on the IL-15 cytokine for development and function. Here we show that these CD8⁺ Treg cells express a triad of surface receptors--CD44, CD122, and the class I MHC receptor Ly49--and account for <5% of CD8⁺ T cells. 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Moreover, the development of systemic lupus erythematosus-like disease in B6-Yaa mutant mice is associated with a pronounced defect in CD8⁺ Treg cell activity, suggesting that this regulatory subset may represent an effective therapeutic approach to systemic lupus erythematosus-like autoimmune disease.</description><subject>Animals</subject><subject>Autoantibodies</subject><subject>Autoimmune diseases</subject><subject>Autoimmunity - genetics</subject><subject>B lymphocytes</subject><subject>Biological Sciences</subject><subject>CD122 antigen</subject><subject>CD8 antigen</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Cytokines</subject><subject>Gene expression</subject><subject>Immune system</subject><subject>Immunology</subject><subject>Immunoregulation</subject><subject>Interleukin 15</subject><subject>Lupus</subject><subject>Ly-49 antigen</subject><subject>Lymphocytes T</subject><subject>Major histocompatibility complex</subject><subject>Memory</subject><subject>Mice</subject><subject>Mice, Mutant Strains</subject><subject>Natural killer cells</subject><subject>Natural killer T cells</subject><subject>NK Cell Lectin-Like Receptor Subfamily A - immunology</subject><subject>Peptides</subject><subject>Phenotypes</subject><subject>Receptors</subject><subject>Rodents</subject><subject>Spleen cells</subject><subject>T cell receptors</subject><subject>T lymphocytes</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhiMEotvCmRNgceEUOv5IbF8qQfhopUUcaA-cLG882WaVr9pJxR77t_g5_BIctmwLFy62R_PMO555k-QZhTcUJD8eOhviiyotBQX1IFlQ0DTNhYaHyQKAyVQJJg6SwxA2AKAzBY-TA0YZ54LKRXJVvFc_b36Qc-JxPTV27P2WlNg0geD3wWMIZLxEstwKTYrGxvCMfD4tIl3iEGFiO0esR-KwwnKsr5HUHbHT2NdtO3VIBt_H812efrOWtHWJT5JHlW0CPr29j5KLjx_Oi9N0-eXTWfF2mZYZgzGVK4xTWC25qyxq4JBn2impXElZzllGM6YdZrLKUDruVk7wlcBS5U5VuXb8KDnZ6Q7TqkVXYjd625jB1631W9Pb2vyd6epLs-6vDQfOmVZR4PWtgO-vJgyjaeswr8Z22E_BaJBUaEH_T6poB2WKzeSrf8hNP_ku7mGGMhCSsQgd76DS9yF4rPafpmBm281su7mzPVa8uD_rnv_j8z1grryTUyYzDChE4PkO2ITo6p6I6rHL7w4vd_nK9saufR3MxddYyYFqLrUQ_Bea6MWP</recordid><startdate>20110201</startdate><enddate>20110201</enddate><creator>Kim, Hye-Jung</creator><creator>Wang, Xuan</creator><creator>Radfar, Soroosh</creator><creator>Sproule, Thomas J</creator><creator>Roopenian, Derry C</creator><creator>Cantor, Harvey</creator><general>National Academy of Sciences</general><general>National Acad Sciences</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110201</creationdate><title>CD8⁺ T regulatory cells express the Ly49 Class I MHC receptor and are defective in autoimmune prone B6-Yaa mice</title><author>Kim, Hye-Jung ; Wang, Xuan ; Radfar, Soroosh ; Sproule, Thomas J ; Roopenian, Derry C ; Cantor, Harvey</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c520t-7be649a973dfae9030659d878dc1263251529de57f5e7d3dbd43b4ec86d8f69d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Autoantibodies</topic><topic>Autoimmune diseases</topic><topic>Autoimmunity - genetics</topic><topic>B lymphocytes</topic><topic>Biological Sciences</topic><topic>CD122 antigen</topic><topic>CD8 antigen</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>Cytokines</topic><topic>Gene expression</topic><topic>Immune system</topic><topic>Immunology</topic><topic>Immunoregulation</topic><topic>Interleukin 15</topic><topic>Lupus</topic><topic>Ly-49 antigen</topic><topic>Lymphocytes T</topic><topic>Major histocompatibility complex</topic><topic>Memory</topic><topic>Mice</topic><topic>Mice, Mutant Strains</topic><topic>Natural killer cells</topic><topic>Natural killer T cells</topic><topic>NK Cell Lectin-Like Receptor Subfamily A - immunology</topic><topic>Peptides</topic><topic>Phenotypes</topic><topic>Receptors</topic><topic>Rodents</topic><topic>Spleen cells</topic><topic>T cell receptors</topic><topic>T lymphocytes</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Hye-Jung</creatorcontrib><creatorcontrib>Wang, Xuan</creatorcontrib><creatorcontrib>Radfar, Soroosh</creatorcontrib><creatorcontrib>Sproule, Thomas J</creatorcontrib><creatorcontrib>Roopenian, Derry C</creatorcontrib><creatorcontrib>Cantor, Harvey</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Hye-Jung</au><au>Wang, Xuan</au><au>Radfar, Soroosh</au><au>Sproule, Thomas J</au><au>Roopenian, Derry C</au><au>Cantor, Harvey</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CD8⁺ T regulatory cells express the Ly49 Class I MHC receptor and are defective in autoimmune prone B6-Yaa mice</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>2011-02-01</date><risdate>2011</risdate><volume>108</volume><issue>5</issue><spage>2010</spage><epage>2015</epage><pages>2010-2015</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>The immune system includes a subpopulation of CD8⁺ T cells equipped to inhibit the expansion of follicular T helper (TFH) cells, resulting in suppression of autoantibody production and associated lupus-like disease. These CD8⁺ T regulatory (Treg) cells recognize Qa-1/peptide complexes on target TFH cells and depend on the IL-15 cytokine for development and function. Here we show that these CD8⁺ Treg cells express a triad of surface receptors--CD44, CD122, and the class I MHC receptor Ly49--and account for <5% of CD8⁺ T cells. Moreover, the development of systemic lupus erythematosus-like disease in B6-Yaa mutant mice is associated with a pronounced defect in CD8⁺ Treg cell activity, suggesting that this regulatory subset may represent an effective therapeutic approach to systemic lupus erythematosus-like autoimmune disease.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>21233417</pmid><doi>10.1073/pnas.1018974108</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Animals Autoantibodies Autoimmune diseases Autoimmunity - genetics B lymphocytes Biological Sciences CD122 antigen CD8 antigen CD8-Positive T-Lymphocytes - immunology Cytokines Gene expression Immune system Immunology Immunoregulation Interleukin 15 Lupus Ly-49 antigen Lymphocytes T Major histocompatibility complex Memory Mice Mice, Mutant Strains Natural killer cells Natural killer T cells NK Cell Lectin-Like Receptor Subfamily A - immunology Peptides Phenotypes Receptors Rodents Spleen cells T cell receptors T lymphocytes T-Lymphocytes, Regulatory - immunology |
| title | CD8⁺ T regulatory cells express the Ly49 Class I MHC receptor and are defective in autoimmune prone B6-Yaa mice |
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