CD8⁺ T regulatory cells express the Ly49 Class I MHC receptor and are defective in autoimmune prone B6-Yaa mice
The immune system includes a subpopulation of CD8⁺ T cells equipped to inhibit the expansion of follicular T helper (TFH) cells, resulting in suppression of autoantibody production and associated lupus-like disease. These CD8⁺ T regulatory (Treg) cells recognize Qa-1/peptide complexes on target TFH...
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Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2011-02, Vol.108 (5), p.2010-2015 |
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Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The immune system includes a subpopulation of CD8⁺ T cells equipped to inhibit the expansion of follicular T helper (TFH) cells, resulting in suppression of autoantibody production and associated lupus-like disease. These CD8⁺ T regulatory (Treg) cells recognize Qa-1/peptide complexes on target TFH cells and depend on the IL-15 cytokine for development and function. Here we show that these CD8⁺ Treg cells express a triad of surface receptors--CD44, CD122, and the class I MHC receptor Ly49--and account for |
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ISSN: | 0027-8424 1091-6490 |
DOI: | 10.1073/pnas.1018974108 |