CD8⁺ T regulatory cells express the Ly49 Class I MHC receptor and are defective in autoimmune prone B6-Yaa mice

The immune system includes a subpopulation of CD8⁺ T cells equipped to inhibit the expansion of follicular T helper (TFH) cells, resulting in suppression of autoantibody production and associated lupus-like disease. These CD8⁺ T regulatory (Treg) cells recognize Qa-1/peptide complexes on target TFH...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 2011-02, Vol.108 (5), p.2010-2015
Hauptverfasser: Kim, Hye-Jung, Wang, Xuan, Radfar, Soroosh, Sproule, Thomas J, Roopenian, Derry C, Cantor, Harvey
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Sprache:eng
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Zusammenfassung:The immune system includes a subpopulation of CD8⁺ T cells equipped to inhibit the expansion of follicular T helper (TFH) cells, resulting in suppression of autoantibody production and associated lupus-like disease. These CD8⁺ T regulatory (Treg) cells recognize Qa-1/peptide complexes on target TFH cells and depend on the IL-15 cytokine for development and function. Here we show that these CD8⁺ Treg cells express a triad of surface receptors--CD44, CD122, and the class I MHC receptor Ly49--and account for
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1018974108