Monomer adds to preformed structured oligomers of Aβ-peptides by a two-stage dock-lock mechanism

Nonfibrillar soluble oligomers, which are intermediates in the transition from monomers to amyloid fibrils, may be the toxic species in Alzheimer's disease. To monitor the early events that direct assembly of amyloidogenic peptides we probe the dynamics of formation of (Aβ₁₆₋₂₂)n by adding a mo...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-01, Vol.104 (1), p.111-116
Hauptverfasser:	Nguyen, Phuong H, Li, Mai Suan, Stock, Gerhard, Straub, John E, Thirumalai, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological Sciences Docks Hydrogen bonds Kinetics Mathematical minima Monomers Oligomers Solar fibrils Trajectories Trimers
Online-Zugang:	Volltext
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