Surfing on Protein Folding Energy Landscapes

A major question occupying the protein folding community is the relative importance of protein topology and sequence in determining the folding mechanism of proteins. Schymkowitz, Rousseau, and Serrano discuss recent research that investigates the contribution of protein topology and protein sequenc...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2002-12, Vol.99 (25), p.15846-15848
Hauptverfasser:	Joost W. H. Schymkowitz, Rousseau, Frederic, Serrano, Luis
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Archaeal Proteins Biochemistry Commentaries DNA-Binding Proteins - chemistry Energy Metabolism Frustration Hydrophobic and Hydrophilic Interactions Kinetics Medical research Modeling Models, Biological Molecular dynamics Protein Conformation Protein engineering Protein Folding Proteins Proto-Oncogene Proteins pp60(c-src) - chemistry Sloping terrain Spectrin - chemistry src Homology Domains Thermodynamics Topology Water
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Beschreibung
Zusammenfassung:	A major question occupying the protein folding community is the relative importance of protein topology and sequence in determining the folding mechanism of proteins. Schymkowitz, Rousseau, and Serrano discuss recent research that investigates the contribution of protein topology and protein sequence to the frustration of energy landscapes.
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.012686599