Highly diastereoselective synthesis of 2-monosubstituted 1R,5S(1S,5R)-glycoluriles on the basis of S- and R-N-carbamoyl-α-amino acids

The reactions of 4,5-dihydroxyimidazolidin-2-one with chiral S - and R - N -carbamoyl-α-amino acids occur diastereoselectively with the formation of corresponding 1 R ,5 S (1 S ,5 R )-glycoluriles as predominant diastereomers; the absolute configuration is determined for three stereoisomers by X-ray diffraction analysis.