Cyclic (4 S)-chloromethyl sulfite and sulfate derivatives of ( S)-glycidol as valuable synthetic equivalents of scalemic epichlorohydrin

Cyclic (4 S)-chloromethyl sulfite and sulfate derivatives of ( S)-glycidol as valuable synthetic equivalents of scalemic epichlorohydrin

The interaction of ( S)-glycidol with SOCl 2 or SO 2Cl 2 in stoichiometric amounts leads to the formation of cyclic (4 S)-chloromethyl sulfite or sulfate derivatives with the same enantiomeric purity; based on this reaction, a new procedure for the synthesis of ( S)-propranolol was developed.

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Veröffentlicht in:Mendeleev communications 1999, Vol.9 (6), p.236-237
Hauptverfasser: Bredikhin, Alexander A., Lazarev, Sergey N., Pashagin, Alexander V., Bredikhina, Zemfira A.
Format: Artikel
Sprache:eng
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Zusammenfassung:The interaction of ( S)-glycidol with SOCl 2 or SO 2Cl 2 in stoichiometric amounts leads to the formation of cyclic (4 S)-chloromethyl sulfite or sulfate derivatives with the same enantiomeric purity; based on this reaction, a new procedure for the synthesis of ( S)-propranolol was developed.
ISSN:0959-9436
DOI:10.1070/MC1999v009n06ABEH001190