Oxiranes in the Ritter reaction: synthesis of 6,7-(or 5,8-)dimethoxy-3,4-dihydroisoquinolines by a tandem alkylation–cyclization procedure

Oxiranes in the Ritter reaction: synthesis of 6,7-(or 5,8-)dimethoxy-3,4-dihydroisoquinolines by a tandem alkylation–cyclization procedure

Treatment of 1,2- (or 1,4)-dimethoxybenzene with isobutylene oxide and an appropriate nitrile RCN in concentrated sulfuric acid leads to 1-R-6,7-(or 5,8-)dimethoxy-3,3-dimethyl-3,4-dihydroisoquinolines.

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Veröffentlicht in:Mendeleev communications 1998, Vol.8 (1), p.17-18
Hauptverfasser: Glushkov, Vladimir A., Shklyaev, Yurii V.
Format: Artikel
Sprache:eng
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Zusammenfassung:Treatment of 1,2- (or 1,4)-dimethoxybenzene with isobutylene oxide and an appropriate nitrile RCN in concentrated sulfuric acid leads to 1-R-6,7-(or 5,8-)dimethoxy-3,3-dimethyl-3,4-dihydroisoquinolines.
ISSN:0959-9436
DOI:10.1070/MC1998v008n01ABEH000881