Methyl 2-trifluoromethylaziridine-2-carboxylate: stereodirected N-halogenation from the sterically more hindered side

Methyl 2-trifluoromethylaziridine-2-carboxylate: stereodirected N-halogenation from the sterically more hindered side

N-Fluorination and N-chlorination of methyl 2-trifluoromethylaziridine-2-carboxylate occurs predominantly from the more hindered side owing to the fixed orientation of the lone electron pair of the N atom caused by the formation of an intramolecular H-bond.

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Veröffentlicht in:Mendeleev communications 1997, Vol.7 (6), p.229-230
Hauptverfasser: Rozhkov, Vladimir V., Makarov, Kirill N., Osipov, Sergey N., Chervin, Ivan I., Ignatenko, Anatolii V., Kostyanovsky, Remir G.
Format: Artikel
Sprache:eng
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Zusammenfassung:N-Fluorination and N-chlorination of methyl 2-trifluoromethylaziridine-2-carboxylate occurs predominantly from the more hindered side owing to the fixed orientation of the lone electron pair of the N atom caused by the formation of an intramolecular H-bond.
ISSN:0959-9436
DOI:10.1070/MC1997v007n06ABEH000831